MORINIDAZOLE 吗啉硝唑

MORINIDAZOLE
吗啉硝唑

(迈灵达^®

1- [3- (4-morpholinyl) -2-hydroxypropyl] -2-methyl-5- nitro -1H- imidazole
CAS 92478-27-8
Jiangsu Hansoh Pharmaceutical Co., Ltd.
Morinidazole was approved by China Food and Drug Administration (CFDA) on February 24, 2014. It was developed and marketed as a step Lingda ® by Hansoh Pharmaceutical.
A nitroimidazoles antibiotic used to treat bacterial infections including appendicitis and pelvic inflammatory disease.

Morinidazole is a nitroimidazoles antibiotic indicated for the treatment of bacterial infections including appendicitis and pelvic inflammatory disease (PID) caused by anaerobic bacteria.



PATENT
WO2006058457A1.
http://www.google.com/patents/WO2006058457A1?cl=en
……………………….
PATENT
CN1981764A.
https://www.google.com/patents/CN1981764A?cl=en
1- (2,3-epoxypropoxy yl) -2-methyl-5-nitro-imidazole (10g), morpholino (10g), 100ml of acetonitrile under reflux for 2 hours, vacuum recovery of acetonitrile, water was added 100ml, heating to the whole solution, filtered hot, let cool, filtering, washing and drying to obtain an off-white solid (11g).
Proton nuclear magnetic resonance data: 1HNMR (CD3Cl) δ2.39 ~ 2.73 (6H, m) δ2.61 (3H, s) δ3.71 ~ 3.81 (4H, m) δ4.10 ~ 4.17 (2H, m) δ4 .63 ~ 4.66 (1H, m) δ8.00 (1H, s)

CN 102199147
http://www.google.com/patents/CN102199147A?cl=en

CN 1605586
https://www.google.com/patents/CN1605586A?cl=en
Example 7 Preparation of α- (morpholino-1-yl) methyl-2-methyl-5-nitroimidazole-1-ethanol according to Example 4 the same manner as in Preparation α- (morpholino-1-yl) methyl-2-methyl-5-nitroimidazole-1-ethanol, except for using morpholine instead of 4-hydroxypiperidine, prepared by the present invention Compound 7. Proton nuclear magnetic resonance data: 1HNMR (CD3Cl) δ2.39 ~ 2.73 (6H, m) δ2.61 (3H, s) δ3.71 ~ 3.81 (4H, m) δ4.10 ~ 4.17 (2H, m) δ4

Jiangsu Hansoh Pharmaceutical Co., Ltd.

NMR PREDICT



1H NMR  PREDICT


13C NMR PREDICT


COSY

CN1810815B	Mar 8, 2006	Mar 16, 2011	陕西合成药业有限公司	Nitroimidazole derivative for treatment
CN1903846B	Aug 15, 2006	Jul 13, 2011	杨成	Ornidazole derivative used for therapy, its preparation method and use
CN100387233C	Jun 9, 2006	May 14, 2008	南京圣和药业有限公司	Use of levo morpholine nidazole for preparing medicine for antiparasitic infection
CN100427094C	Dec 13, 2005	Oct 22, 2008	江苏豪森药业股份有限公司	Usage of alpha-(Morpholin-1-base) methyl-2-methyl-5-azathio-1-alcohol in preparation of anti-trichomoniasis and anti-ameba medicines
CN100540549C	Dec 15, 2005	Sep 16, 2009	南京圣和药业有限公司	Alpha-substituted-2-methyl-5-nitro-diazole-1-alcohol derivative with optical activity
WO2007079653A1 *	Dec 25, 2006	Jul 19, 2007	Junda Cen	OPTICALLY PURE α-SUBSTITUTED 2-METHYL-5-NITROIMIDAZOLE-1-ETHANOL DERIVATIVES

Share this: