FK-3311
FK 3311; 116686-15-8; FK-3311; N-[4-acetyl-2-(2,4-difluorophenoxy)phenyl]methanesulfonamide; COX-2 Inhibitor V, FK3311; FK3311;
| Molecular Formula: | C15H13F2NO4S |
|---|---|
| Molecular Weight: | 341.329826 g/mol |
This compound has been obtained by two different ways: 1) The oxidation of 4′-amino-3′-chloroacetophenone (I) with NaNO2 and HCl in water gives 3′-chloro-4-nitroacetophenone (II), which is condensed with 2,4-difluorophenol (III) by means of K2CO3 in xylene yielding 3′-(2,4-difluorophenyl)-4′-nitroacetophenone (IV). The reduction of (IV) with Fe and NH4Cl in ethanol affords the corresponding 4′-amino compound (V), which is finally treated with methanesulfonyl chloride and pyridine. 2) The reaction of 4′-aminoacetophenone (VI) with methanesulfonyl chloride as before gives the corresponding sulfonamide (VII), which is brominated with Br2 in acetic acid yielding N-(4-acetyl-3-bromophenyl)methanesulfonamide (VIII). Finally, this compound is condensed with 2,4-difluorophenol (III) by means of K2CO3 and CuCl as before.
Chem Pharm Bull 1992,40(9),2399
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| Patent | Submitted | Granted |
|---|---|---|
| METHODS TO TREAT INFECTIONS [US2014329777] | 2014-04-22 | 2014-11-06 |
| NOVEL NIMESULIDE COMPOSITIONS [US2012063996] | 2011-07-28 | 2012-03-15 |
| NANOPARTICULATE MELOXICAM FORMULATIONS [US2014141083] | 2013-07-12 | 2014-05-22 |
| Alkanesulfonanilide derivatives, processes for preparation thereof and pharmaceutical composition comprising the same [US4866091] | 1989-09-12 | |
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