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Tuesday, 17 November 2015

New route for Expensive drug Ivacaftor synthesis from CSIR-NCL, Pune, India



Cover image for Vol. 2015 Issue 32

Ivacaftor.svg
IVACAFTOR

Breaking and Making of Rings: A Method for the Preparation of 4-Quinolone-3-carb­oxylic Acid Amides and the Expensive Drug Ivacaftor

  1. N. Vasudevan,
  2. Gorakhnath R. Jachak and
  3. D. Srinivasa Reddy*
Article first published online: 3 NOV 2015
DOI: 10.1002/ejoc.201501048
http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201501048/abstract
SUPPORTING INFO……….http://onlinelibrary.wiley.com/store/10.1002/ejoc.201501048/asset/supinfo/ejoc_201501048_sm_miscellaneous_information.pdf?v=1&s=2b5b6ac6456ec88f478c07a692e49254e7239f80

Abstract

A simple and convenient method to access 4-quinolone-3-carboxylic acid amides from indole-3-acetic acid amides through one-pot oxidative cleavage of the indole ring followed by condensation (Witkop–Winterfeldt type oxidation) was explored. The scope of the method was confirmed with more than 20 examples and was successfully applied to the synthesis of the drug Ivacaftor, the most expensive drug on the market.






REFERENCES

N. Vasudevan, Gorakhnath R. Jachak And D. Srinivasa Reddy, Breaking and Making of Rings: A Method for the Preparation of 4-Quinolone-3-carb­oxylic Acid Amides and the Expensive Drug Ivacaftor, Eur. J. Org. Chem., , 0000 (2015), DOI:10.1002/ejoc.201501048.
http://academic.ncl.res.in/publications/index/select-faculty/2015/ocd

Breaking and Making of Rings: A Method for the Preparation …

onlinelibrary.wiley.com › … › Early View
6 days ago – European Journal of Organic Chemistry … 20 examples and was successfully applied to the synthesis of the drug Ivacaftor, the most expensive …

European Journal of Organic Chemistry – Wiley Online Library

onlinelibrary.wiley.com › … › European Journal of Organic Chemistry
European Journal of Organic Chemistry ….. examples and is successfully applied to the synthesis of the drug Ivacaftor, the most expensive drug on the market.

Breaking and making – Wiley Online Library

onlinelibrary.wiley.com › … › Early View › Abstract
6 days ago – … for the Preparation of 4-Quinolone-3-carboxylic Acid Amides and the Expensive Drug IvacaftorEuropean Journal of Organic Chemistry.

READ ABOUT DR SRINIVASA REDDY at…………

ONE ORGANIC CHEMIST ONE DAY BLOG……..LINK

Dr. Srinivasa Reddy of CSIR-NCL bags the

prestigious Shanti Swarup Bhatnagar Prize

The award comprises a citation, a plaque, a cash prize of Rs 5 lakh
dr
The Shanti Swarup Bhatnagar Prize for the year 2015 in chemical sciences has been awarded to Dr. D. Srinivasa Reddy of CSIR-National Chemical Laboratory (CSIR-NCL), Pune for his outstanding contributions to the area of total synthesis of natural products and medicinal chemistry.
This is a most prestigious award given to the scientists under 45 years of age and who have demonstrated exceptional potential in Science and Technology. The award derives its value from its rich legacy of those who won this award before and added enormous value to Indian Science.
Dr. Reddy will be bestowed with the award at a formal function, which shall be presided over by the honourable Prime Minister. The award, named after the founder director general of Council of Scientific & Industrial Research (CSIR), Dr. Shanti Swarup Bhatnagar, comprises a citation, a plaque, a cash prize of Rs 5 lakh.
Dr. Reddy’s research group current interests are in the field of total synthesis and drug discovery by applying medicinal chemistry. He has also been involved in the synthesis of the agrochemicals like small molecules for crop protection. The total synthesis of more than twenty natural products has been achieved in his lab including a sex pheromone that attracts the mealy bugs and has potential use in the crop protection. On the medicinal chemistry front significant progress has been made by his group using a new concept called “Silicon-switch approach” towards central nervous system drugs. Identification of New Chemical Entities for the potential treatment of diabetes and infectious diseases is being done in collaboration with industry partners.
His efforts are evidenced by 65 publications and 30 patents. He has recently received the NASI-Reliance industries platinum jubilee award-2015 for application oriented innovations and the CRSI bronze medal. In addition, he is also the recipient of Central Drug Research Institute award for excellence in the drug research in chemical sciences and scientist of the year award by the NCL Research Foundation in the year 2013. Dr. Reddy had worked with pharmaceutical companies for seven years before joining CSIR-NCL in 2010.
AN INTRODUCTION
Ph.D., University of Hyderabad, 2000 (Advisor: Professor Goverdhan Mehta).
Post-doctoral with Profs. Sergey A. Kozmin(University of Chicago, USA) and Prof.
Jeffrey Aubé (University of Kansas, USA)
Experienced in leading drug discovery programs (Dr. Reddy’s & TATA Advinus – 7
years of pharma experience)
Acquired skills in designing novel small molecules and lead optimization
Experienced in planning and execution of total synthesis of biologically active
molecules with moderate complexity
One of the molecules is currently in human clinical trials.
MYSELF WITH HIM
s reddy ncl
DEC2014 NCL PUNE INDIA
DR ANTHONY MELVIN WITH DR SRINIVASA REDDY

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