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Showing posts with label 吗啉硝唑. Show all posts
Showing posts with label 吗啉硝唑. Show all posts

Friday, 4 December 2015

MORINIDAZOLE 吗啉硝唑


S1
Stockhausen's Mai 1.1 of the innovative spirit of antimicrobial agents (morpholine metronidazole) chemical structure
MORINIDAZOLE
吗啉硝唑

(迈灵达®
1- [3- (4-morpholinyl) -2-hydroxypropyl] -2-methyl-5- nitro -1H- imidazole
CAS 92478-27-8
Jiangsu Hansoh Pharmaceutical Co., Ltd.
Morinidazole was approved by China Food and Drug Administration (CFDA) on February 24, 2014. It was developed and marketed as a step Lingda ® by Hansoh Pharmaceutical.
A nitroimidazoles antibiotic used to treat bacterial infections including appendicitis and pelvic inflammatory disease.
Morinidazole is a nitroimidazoles antibiotic indicated for the treatment of bacterial infections including appendicitis and pelvic inflammatory disease (PID) caused by anaerobic bacteria.
str1
MORINI SYN

PATENT
WO2006058457A1.
http://www.google.com/patents/WO2006058457A1?cl=en
……………………….
PATENT
CN1981764A.
https://www.google.com/patents/CN1981764A?cl=en
1- (2,3-epoxypropoxy yl) -2-methyl-5-nitro-imidazole (10g), morpholino (10g), 100ml of acetonitrile under reflux for 2 hours, vacuum recovery of acetonitrile, water was added 100ml, heating to the whole solution, filtered hot, let cool, filtering, washing and drying to obtain an off-white solid (11g).
Proton nuclear magnetic resonance data: 1HNMR (CD3Cl) δ2.39 ~ 2.73 (6H, m) δ2.61 (3H, s) δ3.71 ~ 3.81 (4H, m) δ4.10 ~ 4.17 (2H, m) δ4 .63 ~ 4.66 (1H, m) δ8.00 (1H, s)

CN 102199147
http://www.google.com/patents/CN102199147A?cl=en

CN 1605586
https://www.google.com/patents/CN1605586A?cl=en
Example 7 Preparation of α- (morpholino-1-yl) methyl-2-methyl-5-nitroimidazole-1-ethanol according to Example 4 the same manner as in Preparation α- (morpholino-1-yl) methyl-2-methyl-5-nitroimidazole-1-ethanol, except for using morpholine instead of 4-hydroxypiperidine, prepared by the present invention Compound 7. Proton nuclear magnetic resonance data: 1HNMR (CD3Cl) δ2.39 ~ 2.73 (6H, m) δ2.61 (3H, s) δ3.71 ~ 3.81 (4H, m) δ4.10 ~ 4.17 (2H, m) δ4

Jiangsu Hansoh Pharmaceutical Co., Ltd.
MORINI SYN
NMR PREDICT
CHEMDOODLE


1H NMR  PREDICT
1H NMR GRAPH 1H NMR VAL

13C NMR PREDICT
13C NMR VAL
13C NMR GRAPH
COSY
COSY NMR prediction (23)
CN1810815B Mar 8, 2006 Mar 16, 2011 陕西合成药业有限公司 Nitroimidazole derivative for treatment
CN1903846B Aug 15, 2006 Jul 13, 2011 杨成 Ornidazole derivative used for therapy, its preparation method and use
CN100387233C Jun 9, 2006 May 14, 2008 南京圣和药业有限公司 Use of levo morpholine nidazole for preparing medicine for antiparasitic infection
CN100427094C Dec 13, 2005 Oct 22, 2008 江苏豪森药业股份有限公司 Usage of alpha-(Morpholin-1-base) methyl-2-methyl-5-azathio-1-alcohol in preparation of anti-trichomoniasis and anti-ameba medicines
CN100540549C Dec 15, 2005 Sep 16, 2009 南京圣和药业有限公司 Alpha-substituted-2-methyl-5-nitro-diazole-1-alcohol derivative with optical activity
WO2007079653A1 * Dec 25, 2006 Jul 19, 2007 Junda Cen OPTICALLY PURE α-SUBSTITUTED 2-METHYL-5-NITROIMIDAZOLE-1-ETHANOL DERIVATIVES




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