IVACAFTOR
Breaking and Making of Rings: A Method for the Preparation of 4-Quinolone-3-carboxylic Acid Amides and the Expensive Drug Ivacaftor
Article first published online: 3 NOV 2015
DOI: 10.1002/ejoc.201501048
SUPPORTING INFO……….http://onlinelibrary.wiley.com/store/10.1002/ejoc.201501048/asset/supinfo/ejoc_201501048_sm_miscellaneous_information.pdf?v=1&s=2b5b6ac6456ec88f478c07a692e49254e7239f80
Abstract
A simple and convenient method to access 4-quinolone-3-carboxylic
acid amides from indole-3-acetic acid amides through one-pot oxidative
cleavage of the indole ring followed by condensation (Witkop–Winterfeldt
type oxidation) was explored. The scope of the method was confirmed
with more than 20 examples and was successfully applied to the synthesis
of the drug Ivacaftor, the most expensive drug on the market.
REFERENCES
N. Vasudevan, Gorakhnath R. Jachak And D. Srinivasa Reddy, Breaking and Making of Rings: A Method for the Preparation of 4-Quinolone-3-carboxylic Acid Amides and the Expensive Drug Ivacaftor, Eur. J. Org. Chem., , 0000 (2015), DOI:10.1002/ejoc.201501048.
http://academic.ncl.res.in/publications/index/select-faculty/2015/ocd
Breaking and Making of Rings: A Method for the Preparation …
onlinelibrary.wiley.com › … › Early View
6 days ago – European Journal of Organic Chemistry … 20 examples and was successfully applied to the synthesis of the drug Ivacaftor, the most expensive …European Journal of Organic Chemistry – Wiley Online Library
onlinelibrary.wiley.com › … › European Journal of Organic Chemistry
Breaking and making – Wiley Online Library
onlinelibrary.wiley.com › … › Early View › Abstract
6 days ago – … for the Preparation of 4-Quinolone-3-carboxylic Acid Amides and the Expensive Drug Ivacaftor … European Journal of Organic Chemistry.READ ABOUT DR SRINIVASA REDDY at…………
ONE ORGANIC CHEMIST ONE DAY BLOG……..LINKDr. Srinivasa Reddy of CSIR-NCL bags the
prestigious Shanti Swarup Bhatnagar Prize
sept 2015…………..http://www.biospectrumindia.com/biospecindia/news/222486/
The award comprises a citation, a plaque, a cash prize of Rs 5 lakh
The Shanti Swarup Bhatnagar Prize for the year 2015 in chemical
sciences has been awarded to Dr. D. Srinivasa Reddy of CSIR-National
Chemical Laboratory (CSIR-NCL), Pune for his outstanding contributions
to the area of total synthesis of natural products and medicinal
chemistry.
This is a most prestigious award given to the scientists under 45
years of age and who have demonstrated exceptional potential in Science
and Technology. The award derives its value from its rich legacy of
those who won this award before and added enormous value to Indian
Science.
Dr. Reddy will be bestowed with the award at a formal function,
which shall be presided over by the honourable Prime Minister. The
award, named after the founder director general of Council of Scientific
& Industrial Research (CSIR), Dr. Shanti Swarup Bhatnagar,
comprises a citation, a plaque, a cash prize of Rs 5 lakh.
Dr. Reddy’s research group current interests are in the field of
total synthesis and drug discovery by applying medicinal chemistry. He
has also been involved in the synthesis of the agrochemicals like small
molecules for crop protection. The total synthesis of more than twenty
natural products has been achieved in his lab including a sex pheromone
that attracts the mealy bugs and has potential use in the crop
protection. On the medicinal chemistry front significant progress has
been made by his group using a new concept called “Silicon-switch
approach” towards central nervous system drugs. Identification of New
Chemical Entities for the potential treatment of diabetes and infectious
diseases is being done in collaboration with industry partners.
His efforts are evidenced by 65 publications and 30 patents. He has
recently received the NASI-Reliance industries platinum jubilee
award-2015 for application oriented innovations and the CRSI bronze
medal. In addition, he is also the recipient of Central Drug Research
Institute award for excellence in the drug research in chemical sciences
and scientist of the year award by the NCL Research Foundation in the
year 2013. Dr. Reddy had worked with pharmaceutical companies for seven
years before joining CSIR-NCL in 2010.
Ph.D., University of Hyderabad, 2000 (Advisor: Professor Goverdhan Mehta).
Post-doctoral with Profs. Sergey A. Kozmin(University of Chicago, USA) and Prof.
Post-doctoral with Profs. Sergey A. Kozmin(University of Chicago, USA) and Prof.
Jeffrey Aubé (University of Kansas, USA)
Experienced in leading drug discovery programs (Dr. Reddy’s & TATA Advinus – 7
Experienced in leading drug discovery programs (Dr. Reddy’s & TATA Advinus – 7
years of pharma experience)
Acquired skills in designing novel small molecules and lead optimization
Experienced in planning and execution of total synthesis of biologically active
Acquired skills in designing novel small molecules and lead optimization
Experienced in planning and execution of total synthesis of biologically active
molecules with moderate complexity
One of the molecules is currently in human clinical trials.
One of the molecules is currently in human clinical trials.
MYSELF WITH HIM
DEC2014 NCL PUNE INDIA
DR ANTHONY MELVIN WITH DR SRINIVASA REDDY
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